Tomoyuki Kakugawa Selected Research

HSP47 Heat-Shock Proteins (Heat Shock Protein 47)

1/2022	Investigating the role of heat shock protein 47 in fibrosis in Crohn's disease.
3/2014	Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia.
11/2013	Serum heat shock protein 47 levels in patients with drug-induced lung disease.
9/2013	Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis.
4/2007	Alpha-defensin enhances expression of HSP47 and collagen-1 in human lung fibroblasts.

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Tomoyuki Kakugawa Research Topics

Disease

18	Interstitial Lung Diseases (Interstitial Lung Disease) 04/2020 - 10/2004
13	Idiopathic Pulmonary Fibrosis 01/2022 - 10/2004
8	Fibrosis (Cirrhosis) 01/2022 - 10/2003
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2014 - 10/2003
5	Dyspnea (Shortness of Breath) 01/2017 - 10/2005
5	Vascular Diseases (Vascular Disease) 05/2015 - 07/2002
4	Neoplasms (Cancer) 04/2022 - 01/2014
4	Pneumonia (Pneumonitis) 09/2021 - 10/2005
4	Sarcoidosis (Schaumann Disease) 11/2020 - 10/2004
4	Dermatomyositis (Dermatopolymyositis) 11/2017 - 09/2004
4	Lung Diseases (Lung Disease) 11/2013 - 03/2005
3	Chronic Obstructive Pulmonary Disease (COPD) 08/2020 - 05/2009
3	Bronchiectasis 04/2020 - 01/2017
3	Cryptogenic Organizing Pneumonia 05/2015 - 11/2008
3	Amyopathic dermatomyositis 01/2015 - 09/2004
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 04/2013 - 03/2009
2	Granuloma 01/2022 - 01/2010
2	Lung Neoplasms (Lung Cancer) 09/2020 - 04/2020
2	Rheumatoid Arthritis 01/2019 - 05/2012
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2018 - 01/2014
2	Myositis (Idiopathic Inflammatory Myopathies) 03/2018 - 12/2011
2	Fatigue 01/2017 - 10/2005
2	Bacterial Pneumonia 01/2016 - 02/2008
2	Muscle Weakness 01/2016 - 12/2011
2	Infections 01/2016 - 02/2015
2	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2016 - 05/2015
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2015 - 05/2009
2	Cough 11/2012 - 10/2005
2	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 01/2010 - 10/2005
1	Aspiration Pneumonia 10/2022
1	Thrombosis (Thrombus) 04/2022
1	Thymoma (Thymic Carcinoma) 04/2022
1	Shock 04/2022
1	Superior Vena Cava Syndrome (Superior Vena Cava Obstruction) 04/2022
1	Otitis Media 01/2022
1	Asthma (Bronchial Asthma) 01/2022
1	Pathologic Constriction (Stenosis) 01/2022
1	Crohn Disease (Crohn's Disease) 01/2022
1	Sinusitis 01/2022
1	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 01/2022
1	Vasculitis (Vasculitides) 11/2020
1	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/2019
1	Idiopathic Interstitial Pneumonias 11/2017
1	Leiomyosarcoma 01/2017
1	Pneumothorax 01/2017
1	Neoplasm Metastasis (Metastasis) 01/2017

Drug/Important Bio-Agent (IBA)

12	CollagenIBA 01/2022 - 07/2002
8	Biomarkers (Surrogate Marker)IBA 08/2020 - 11/2008
7	EnzymesIBA 03/2018 - 09/2004
6	Proteins (Proteins, Gene)FDA Link 08/2020 - 10/2003
6	Pharmaceutical PreparationsIBA 04/2020 - 10/2005
5	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 01/2022 - 04/2007
5	ImmunosorbentsIBA 03/2018 - 10/2004
4	Polymyxin B (Aerosporin)FDA LinkGeneric 01/2022 - 01/2008
4	Peptides (Polypeptides)IBA 03/2018 - 11/2006
3	AntigensIBA 09/2021 - 05/2009
3	Methotrexate (Mexate)FDA LinkGeneric 01/2019 - 12/2011
3	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 03/2018 - 02/2015
3	DefensinsIBA 03/2018 - 02/2015
3	AntibodiesIBA 11/2017 - 01/2010
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2016 - 02/2008
3	Clarithromycin (Biaxin)FDA LinkGeneric 01/2016 - 01/2008
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2016 - 01/2011
3	SteroidsIBA 10/2014 - 12/2011
3	pirfenidoneIBA 01/2014 - 01/2008
3	Bleomycin (Blenoxane)FDA LinkGeneric 06/2012 - 03/2010
3	Collagen Type I (Type I Collagen)IBA 06/2012 - 01/2008
2	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2022 - 11/2020
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2020 - 06/2010
2	Indicators and Reagents (Reagents)IBA 03/2018 - 10/2003
2	Immunosuppressive Agents (Immunosuppressants)IBA 11/2016 - 01/2014
2	InterferonsIBA 01/2016 - 01/2015
2	MacrolidesIBA 01/2016 - 01/2014
2	Interleukin-8 (Interleukin 8)IBA 12/2015 - 05/2015
2	beta-DefensinsIBA 02/2015 - 03/2005
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 06/2012 - 01/2008
2	Prednisolone (Predate)FDA LinkGeneric 12/2011 - 10/2005
2	alpha-DefensinsIBA 09/2010 - 04/2007
2	Messenger RNA (mRNA)IBA 03/2010 - 10/2003
2	indium-bleomycinIBA 03/2010 - 10/2003
2	CXC ChemokinesIBA 11/2006 - 09/2005
2	Interferon-gamma (Interferon, gamma)IBA 11/2006 - 09/2005
1	galactomannanIBA 10/2022
1	polyglucosanIBA 10/2022
1	AnticoagulantsIBA 04/2022
1	Monoclonal AntibodiesIBA 01/2022
1	Biological ProductsIBA 01/2022
1	Interleukin-5 (Interleukin 5)IBA 01/2022
1	16S Ribosomal RNAIBA 11/2020
1	Growth Differentiation Factor 15IBA 08/2020
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 01/2019
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2018
1	Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)IBA 03/2018

Therapy/Procedure

7	Therapeutics 09/2021 - 03/2009
4	Hemoperfusion 01/2022 - 01/2008
3	Traction 04/2020 - 01/2017
2	Drug Therapy (Chemotherapy) 04/2022 - 04/2020
1	Radiotherapy 04/2022
1	Neoadjuvant Therapy 04/2022
1	Biological Therapy 01/2022